2021 Jul 1; 11 560201
generic for cialis R is C 1 to C 12 alkyl, C 2 to C 12 alkenyl, C 2 to C 12 alkynyl, C 1 to C 12 substituted alkyl, C 2 to C 12 substituted alkenyl, C 2 to C 12 substituted alkynyl, C 7 to C 18 phenylalkyl or C 7 to C 18 substituted phenylalkyl; or R and R 6 may form a heterocycle or substituted heterocycle; or R and R 4 may form a heterocycle or substituted heterocycle; R 1 is hydrogen, alkyl, alkoxy, halo, cyano, nitro, CO 2 R 7, C O NR 7 R 8, CH NR 7, C NR 9 NR 7 R 8, or NR 7 R 8, wherein R 7 and R 8 are, independently, C 1 to C 12 alkyl, C 2 to C 12 alkenyl, C 2 to C 12 alkynyl, C 1 to C 12 substituted alkyl, C 2 to C 12 substituted alkenyl, C 2 to C 12 substituted alkynyl, C 7 to C 18 phenylalkyl or C 7 to C 18 substituted phenylalkyl; or NR 7 R 8 is heterocycle, substituted heterocycle, cyclic C 2 to C 7 heteroalkylene or substituted cyclic C 2 to C 7 heteroalkylene, wherein the substituted heterocycle and substituted cyclic C 2 to C 7 heteroalkylene are defined below and also include oxo and a substitution of the formula NR 9, wherein R 9 is hydrogen, C 1 to C 12 alkyl or C 1 to C 12 substituted alkyl; R 2, R 3, R 4 and R 6 are, independently, hydrogen, C 1 to C 12 alkyl, C 1 to C 12 substituted alkyl, halo or one of the following the formulae a CH 2 n CO 2 R 10; b CH 2 n CON R 10 2; c CH 2 n CN; or d CH 2 n SO 2 R 10; wherein R 10 is hydrogen, C 1 to C 12 alkyl or C 1 to C 12 substituted alkyl and n is 0 to 4; and R 5 is C 1 to C 12 alkyl, C 1 to C 12 substituted alkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, heterocycle, substituted heterocycle, cyclic C 2 to C 7 heteroalkylene or substituted cyclic C 2 to C 7 heteroalkylene